README.txt file was created on 20191108 by Ting-Ting Chi

----- GENERAL INFORMATION -----

# Data Title: Effect of intravenous administration of maropitant on blood pressure in healthy awake and anesthetized dogs


#Data Abstract:
Blood pressure and heart rate documentations of the research. Statistical analysis result of the data collected from the research is also included.


# Authors: 
Author: Ting-Ting Chi	
Institution: Iowa State University. College of Veterinary Medicine.
Address: 1800 Christensen Drive. Ames, Iowa 
Email: schi@iastate.edu


Author: Bonnie Hay-Kraus
Institution: Iowa State University. College of Veterinary Medicine.
Address:1800 Christensen Drive. Ames, Iowa
Email: bhkraus@iastate.edu


Corresponding author: Dr. Chi, Dr. Hay-Kraus

----- DATA COLLECTION ----- 
	Time period(s): 2018 August-2019 March. 
	
	Location: Iowa State University.  College of Veterinary Medicine.  Veterinary Clinical Science.
	
	Objective: To evaluate the effects of intravenous maropitant on arterial blood pressure in healthy dogs when awake and under general anesthesia.

	Design: Experimental crossover study

	Animals: Eight healthy adult Beagle dogs.
	
	Procedure: All dogs received maropitant 1 mg kg-1 intravenously during the following: awake with peripheral invasive blood pressure (BP) (Awake), anesthetized groups with premedication with either acepromazine 0.005 mg kg-1 and butorphanol 0.2 mg kg-1 (GaAB) or dexmedetomidine 0.005 mg kg-1 and butorphanol 0.2 mg kg -1 (GaDB) followed by general anesthesia with isoflurane. Heart rate (HR), systolic (SAP), diastolic (DAP) and mean blood pressures (MAP) were recorded before injection (baseline), during first 60 seconds of injection, during second 60 seconds of injection, at completion of injection and every 2 minutes post injection for 18 minutes in each group. The data were compared over time using Generalized Linear Model with mixed effects and then with simple effect comparison with Bonferroni adjustments (p <0.05)
	
	Data Collection: Blood pressure and Heart Rate were recorded by hand and transferred into Excel.

----- FILE DIRECTORY ----- 
	A. [maropitant statistic data with time contrast.csv] - Statistical result of time comparison between baseline to various time point.
	B. [maropitant statistics data between groups.csv] - Statistical result of between groups comparison.
	C. [Research BP HR data individual dogs anesthetized acepromazine and butorphanol.csv] - Blood pressure and heart rate documentation of anesthetized group acepromazine and butorphanol.
	D. [Research BP HR data individual dogs anesthetized dexmedetomidine and butorphanol.csv] - Blood pressure and heart rate documentation of anesthetized group dexmedetomidine and butorphanol.
	E. [Research BP HR data individual dogs awake IBP.csv] - Heart rate and blood pressure of awake invasive blood pressure group.
	F. [Research BP HR data individual dogs awake NIBP.csv] - Heart rate and blood pressure of awake non-invasive blood pressure group.
	G. [Codebook.csv] - Definitions and explanations for the variables in the other CSV files.
	H. [Maropitant statistics data between groups.pdf] - Statistical analysis of the collected data.

------- Licensing -------
This work is licensed under a Creative Commons Attribution 4.0 International License. http://creativecommons.org/licenses/by/4.0/

------- CHANGE LOG ------- 
This file was edited on 2019-12-04 by Megan O'Donnell (DataShare curator).Changes made: corrected typos and added information from the system record.